Drug interactions
Modafinil + Tofacitinib
Severity: Minor
Modafinil and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak CYP3A4 inducer and a weak CYP2C19 inhibitor, so any change in tofacitinib exposure is likely small and its direction uncertain.
What this interaction means in plain words
Modafinil and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction and weak CYP2C19 inhibition by modafinil with opposing effects.
What to do
No dose adjustment is needed; monitor clinical response and adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Tofacitinib?
MediHelp rates the interaction as minor. Modafinil and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a weak CYP3A4 inducer and a weak CYP2C19 inhibitor, so any change in tofacitinib exposure is likely small and its direction uncertain.
How serious is the interaction between Modafinil and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor clinical response and adverse effects.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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