Drug interactions
Modafinil + Triazolam
Severity: Moderate
Modafinil and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil can weaken the hypnotic effect of triazolam because it promotes wakefulness. Modafinil is also a modest CYP3A4 inducer and may lower triazolam exposure, since triazolam is a sensitive CYP3A4 substrate. The result can be reduced hypnotic efficacy.
What this interaction means in plain words
Modafinil and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects plus weak CYP3A4 induction by modafinil, which may lower triazolam concentrations.
What to do
Monitor for loss of hypnotic effect and adjust triazolam dose if needed. Give modafinil in the morning only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Triazolam?
MediHelp rates the interaction as moderate. Modafinil and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil can weaken the hypnotic effect of triazolam because it promotes wakefulness. Modafinil is also a modest CYP3A4 inducer and may lower triazolam exposure, since triazolam is a sensitive CYP3A4 substrate. The result can be reduced hypnotic efficacy.
How serious is the interaction between Modafinil and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hypnotic effect and adjust triazolam dose if needed. Give modafinil in the morning only.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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