Drug interactions
Modafinil + Triclofos
Severity: Minor
Modafinil and Triclofos: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, whereas modafinil promotes wakefulness. The drugs have opposing effects, so modafinil may blunt the sedative effect of triclofos. Wakefulness may not correspond to normal psychomotor function.
What this interaction means in plain words
Modafinil and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
Avoid giving modafinil near the time of triclofos dosing. Monitor sedation and the effectiveness of triclofos.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Modafinil and Triclofos, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Triclofos?
MediHelp rates the interaction as minor. Modafinil and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, whereas modafinil promotes wakefulness. The drugs have opposing effects, so modafinil may blunt the sedative effect of triclofos. Wakefulness may not correspond to normal psychomotor function.
How serious is the interaction between Modafinil and Triclofos?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving modafinil near the time of triclofos dosing. Monitor sedation and the effectiveness of triclofos.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
