Drug interactions
Modafinil + Trifluoperazine
Severity: Moderate
Modafinil and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine antipsychotic with mild sedative effect, while modafinil is a wake-promoting stimulant. Modafinil may counter sedation but could worsen agitation, anxiety or psychotic symptoms. Antipsychotic efficacy might be undermined in patients with psychosis.
What this interaction means in plain words
Modafinil and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects; modafinil may exacerbate psychiatric symptoms; no established pharmacokinetic mechanism.
What to do
Monitor mental state, agitation and sleep when the two are combined. Reassess modafinil if psychotic symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Trifluoperazine?
MediHelp rates the interaction as moderate. Modafinil and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is a phenothiazine antipsychotic with mild sedative effect, while modafinil is a wake-promoting stimulant. Modafinil may counter sedation but could worsen agitation, anxiety or psychotic symptoms. Antipsychotic efficacy might be undermined in patients with psychosis.
How serious is the interaction between Modafinil and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental state, agitation and sleep when the two are combined. Reassess modafinil if psychotic symptoms worsen.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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