Drug interactions
Modafinil + Yerba mate
Severity: Minor
Modafinil and Yerba mate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yerba mate contains caffeine and related xanthines, which are stimulants. Taken with modafinil it may add to stimulant effects such as insomnia, nervousness, tachycardia or raised blood pressure.
What this interaction means in plain words
Modafinil and Yerba mate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive central nervous system stimulation from caffeine content.
What to do
Advise limiting yerba mate and other caffeine sources, and monitor for insomnia, anxiety and palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Yerba mate?
MediHelp rates the interaction as minor. Modafinil and Yerba mate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yerba mate contains caffeine and related xanthines, which are stimulants. Taken with modafinil it may add to stimulant effects such as insomnia, nervousness, tachycardia or raised blood pressure.
How serious is the interaction between Modafinil and Yerba mate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting yerba mate and other caffeine sources, and monitor for insomnia, anxiety and palpitations.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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