Drug interactions
Modafinil + Yohimbine
Severity: Moderate
Modafinil and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both modafinil and yohimbine have stimulant-like central effects. Combining them may cause additive anxiety, insomnia, tremor, tachycardia and raised blood pressure. Patients with cardiovascular disease or anxiety disorders are at particular risk.
What this interaction means in plain words
Modafinil and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and sympathetic stimulation; yohimbine is an alpha-2 antagonist that increases noradrenergic outflow while modafinil enhances catecholamine signalling.
What to do
Monitor blood pressure, heart rate and anxiety or insomnia symptoms. Avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Yohimbine?
MediHelp rates the interaction as moderate. Modafinil and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both modafinil and yohimbine have stimulant-like central effects. Combining them may cause additive anxiety, insomnia, tremor, tachycardia and raised blood pressure. Patients with cardiovascular disease or anxiety disorders are at particular risk.
How serious is the interaction between Modafinil and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and anxiety or insomnia symptoms. Avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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