Drug interactions
Modafinil + Zanubrutinib
Severity: Major
Modafinil and Zanubrutinib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may lower zanubrutinib exposure and reduce its efficacy. Labeling advises avoiding moderate CYP3A inducers or increasing the zanubrutinib dose.
What this interaction means in plain words
Modafinil and Zanubrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Modafinil belongs to Central Nervous System; Zanubrutinib belongs to Oncology.
Why it happens
Modafinil induces CYP3A4, increasing zanubrutinib clearance.
What to do
Avoid if possible; if unavoidable, increase zanubrutinib to the labeled adjusted dose and return to the usual dose after modafinil is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Modafinil
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Modafinil with Zanubrutinib?
MediHelp rates the interaction as major. Modafinil and Zanubrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil may lower zanubrutinib exposure and reduce its efficacy. Labeling advises avoiding moderate CYP3A inducers or increasing the zanubrutinib dose.
How serious is the interaction between Modafinil and Zanubrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, increase zanubrutinib to the labeled adjusted dose and return to the usual dose after modafinil is stopped.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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