Drug interactions
Moexipril + Torsemide
Severity: Moderate
Moexipril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding moexipril to a loop diuretic can cause marked hypotension, especially after the first dose or with volume depletion. Renal function may also decline.
What this interaction means in plain words
Moexipril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced renin-angiotensin activation is blocked by ACE inhibition, giving additive hypotension and reduced glomerular filtration.
What to do
Monitor blood pressure, creatinine and potassium after starting or titrating, and consider lowering the diuretic dose before initiating moexipril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Torsemide?
MediHelp rates the interaction as moderate. Moexipril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding moexipril to a loop diuretic can cause marked hypotension, especially after the first dose or with volume depletion. Renal function may also decline.
How serious is the interaction between Moexipril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting or titrating, and consider lowering the diuretic dose before initiating moexipril in volume-depleted patients.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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