Drug interactions
Mometasone + Nirmatrelvir / ritonavir
Severity: Moderate
Mometasone and Nirmatrelvir / ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and can raise systemic mometasone exposure. Cushing's syndrome and adrenal suppression are a concern with prolonged use, while a short COVID-19 course carries lower risk.
What this interaction means in plain words
Mometasone and Nirmatrelvir / ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir strongly inhibits intestinal and hepatic CYP3A4, decreasing mometasone clearance.
What to do
For a short course, continue with awareness; for longer use, switch to beclomethasone or prednisolone. Monitor for corticosteroid excess and adrenal suppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Frequently asked questions
Can I take Mometasone with Nirmatrelvir / ritonavir?
MediHelp rates the interaction as moderate. Mometasone and Nirmatrelvir / ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 and can raise systemic mometasone exposure. Cushing's syndrome and adrenal suppression are a concern with prolonged use, while a short COVID-19 course carries lower risk.
How serious is the interaction between Mometasone and Nirmatrelvir / ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For a short course, continue with awareness; for longer use, switch to beclomethasone or prednisolone. Monitor for corticosteroid excess and adrenal suppression.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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