Drug interactions
Mometasone + Nirmatrelvir
Severity: Moderate
Mometasone and Nirmatrelvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is only given with ritonavir, which strongly inhibits CYP3A4 and can raise systemic mometasone exposure. Cushing's syndrome and adrenal suppression are a concern with prolonged coadministration, but a short 5-day course carries lower risk.
What this interaction means in plain words
Mometasone and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mometasone belongs to Respiratory; Nirmatrelvir belongs to Anti Virals.
Why it happens
The ritonavir booster strongly inhibits CYP3A4, reducing mometasone clearance.
What to do
For a short course, continue with awareness of the risk; for longer use, switch to beclomethasone or prednisolone. Monitor for corticosteroid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Mometasone with Nirmatrelvir?
MediHelp rates the interaction as moderate. Mometasone and Nirmatrelvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirmatrelvir is only given with ritonavir, which strongly inhibits CYP3A4 and can raise systemic mometasone exposure. Cushing's syndrome and adrenal suppression are a concern with prolonged coadministration, but a short 5-day course carries lower risk.
How serious is the interaction between Mometasone and Nirmatrelvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For a short course, continue with awareness of the risk; for longer use, switch to beclomethasone or prednisolone. Monitor for corticosteroid excess.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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