Drug interactions
Morphine + Nabilone
Severity: Major
Morphine and Nabilone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and combining them can increase drowsiness, confusion and impaired coordination. Morphine adds a risk of respiratory depression that may be heightened with additional sedatives.
What this interaction means in plain words
Morphine and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Morphine belongs to Musculoskeletal; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate, especially at initiation and after dose increases. Educate patients about avoiding alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nabilone
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Nabilone?
MediHelp rates the interaction as major. Morphine and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress the CNS, and combining them can increase drowsiness, confusion and impaired coordination. Morphine adds a risk of respiratory depression that may be heightened with additional sedatives.
How serious is the interaction between Morphine and Nabilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, especially at initiation and after dose increases. Educate patients about avoiding alcohol and other sedatives.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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