Drug interactions
Morphine + Tipranavir
Severity: Minor
Morphine and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine is mainly glucuronidated rather than metabolized by CYP2D6, so CYP-mediated interaction is unlikely. Tipranavir given with ritonavir may affect P-glycoprotein and glucuronidation, so morphine effect could change unpredictably.
What this interaction means in plain words
Morphine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Morphine belongs to Musculoskeletal; Tipranavir belongs to Anti Virals.
Why it happens
Possible modulation of P-glycoprotein and UGT activity by tipranavir/ritonavir; not well established.
What to do
Monitor analgesic response and signs of opioid toxicity or withdrawal, adjusting the morphine dose to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Morphine with Tipranavir?
MediHelp rates the interaction as minor. Morphine and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Morphine is mainly glucuronidated rather than metabolized by CYP2D6, so CYP-mediated interaction is unlikely. Tipranavir given with ritonavir may affect P-glycoprotein and glucuronidation, so morphine effect could change unpredictably.
How serious is the interaction between Morphine and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and signs of opioid toxicity or withdrawal, adjusting the morphine dose to effect.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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