Drug interactions
Morphine + Ziconotide
Severity: Moderate
Morphine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, an intrathecal N-type calcium channel blocker, can cause sedation, confusion and cognitive impairment. Added to morphine, these effects may be more pronounced, although the combination is used in intrathecal practice.
What this interaction means in plain words
Morphine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; ziconotide acts via N-type calcium channel blockade and morphine via opioid receptors.
What to do
Titrate ziconotide slowly and monitor mental status and level of consciousness; reduce the dose of either drug if sedation or cognitive impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Morphine with Ziconotide?
MediHelp rates the interaction as moderate. Morphine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide, an intrathecal N-type calcium channel blocker, can cause sedation, confusion and cognitive impairment. Added to morphine, these effects may be more pronounced, although the combination is used in intrathecal practice.
How serious is the interaction between Morphine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ziconotide slowly and monitor mental status and level of consciousness; reduce the dose of either drug if sedation or cognitive impairment develops.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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