Drug interactions
Motherwort + Trazodone
Severity: Minor
Motherwort and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort has traditionally been used as a mild sedative, so combined use with trazodone may increase drowsiness. Clinical data are scarce and the interaction is largely theoretical.
What this interaction means in plain words
Motherwort and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the herb's pharmacology is poorly characterised.
What to do
Tell patients about possible added drowsiness and advise against driving until the response is known. Consider stopping the herb if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Motherwort with Trazodone?
MediHelp rates the interaction as minor. Motherwort and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort has traditionally been used as a mild sedative, so combined use with trazodone may increase drowsiness. Clinical data are scarce and the interaction is largely theoretical.
How serious is the interaction between Motherwort and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell patients about possible added drowsiness and advise against driving until the response is known. Consider stopping the herb if sedation is excessive.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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