Drug interactions
Motherwort + Trimipramine
Severity: Minor
Motherwort and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort is a herbal product with reputed sedative properties, and trimipramine is a markedly sedating tricyclic. Combined use may increase drowsiness and impair psychomotor performance, but the evidence is limited.
What this interaction means in plain words
Motherwort and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Presumed additive CNS depressant effects; the herbal constituents are poorly characterized.
What to do
Advise patients about increased drowsiness and to avoid driving or operating machinery until the response is known. Consider avoiding the herbal product if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Motherwort with Trimipramine?
MediHelp rates the interaction as minor. Motherwort and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort is a herbal product with reputed sedative properties, and trimipramine is a markedly sedating tricyclic. Combined use may increase drowsiness and impair psychomotor performance, but the evidence is limited.
How serious is the interaction between Motherwort and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about increased drowsiness and to avoid driving or operating machinery until the response is known. Consider avoiding the herbal product if sedation is excessive.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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