Drug interactions
Moxifloxacin + Naproxen
Severity: Moderate
Moxifloxacin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen taken with moxifloxacin may increase the potential for CNS stimulation and seizures. This is mainly relevant in patients with underlying seizure risk.
What this interaction means in plain words
Moxifloxacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Naproxen belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, possibly augmented by NSAIDs; mechanism not firmly established.
What to do
Avoid in patients with seizure disorders or CNS lesions and consider an alternative antibiotic. Otherwise monitor for agitation, tremor or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Naproxen?
MediHelp rates the interaction as moderate. Moxifloxacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen taken with moxifloxacin may increase the potential for CNS stimulation and seizures. This is mainly relevant in patients with underlying seizure risk.
How serious is the interaction between Moxifloxacin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders or CNS lesions and consider an alternative antibiotic. Otherwise monitor for agitation, tremor or seizures.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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