Drug interactions
Moxifloxacin + Paroxetine
Severity: Moderate
Moxifloxacin and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, though paroxetine has a relatively small effect. Combined use may modestly raise the risk of torsades de pointes in patients with other risk factors.
What this interaction means in plain words
Moxifloxacin and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Paroxetine belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac hERG potassium channels, prolonging ventricular repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium. Monitor the QTc in patients with additional risk factors, or choose another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Paroxetine?
MediHelp rates the interaction as moderate. Moxifloxacin and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, though paroxetine has a relatively small effect. Combined use may modestly raise the risk of torsades de pointes in patients with other risk factors.
How serious is the interaction between Moxifloxacin and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium. Monitor the QTc in patients with additional risk factors, or choose another antibiotic.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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