Drug interactions
Moxifloxacin + Salbutamol
Severity: Moderate
Moxifloxacin and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin prolongs the QT interval, and salbutamol can cause tachycardia and hypokalemia, which raise the risk of torsades de pointes. The risk is greatest with high-dose or nebulised salbutamol, in patients with other QT risk factors.
What this interaction means in plain words
Moxifloxacin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced intracellular potassium shift increasing arrhythmic susceptibility.
What to do
Check potassium and magnesium and correct deficits; obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Consider a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Salbutamol?
MediHelp rates the interaction as moderate. Moxifloxacin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin prolongs the QT interval, and salbutamol can cause tachycardia and hypokalemia, which raise the risk of torsades de pointes. The risk is greatest with high-dose or nebulised salbutamol, in patients with other QT risk factors.
How serious is the interaction between Moxifloxacin and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits; obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Consider a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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