Drug interactions
Moxifloxacin + Tretinoin
Severity: Moderate
Moxifloxacin and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both moxifloxacin and systemic tretinoin can cause photosensitivity, so combined use may increase the risk of exaggerated sunburn-like reactions. The effect is relevant mainly with oral tretinoin and with sun exposure.
What this interaction means in plain words
Moxifloxacin and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Tretinoin belongs to Dermatology.
Why it happens
Additive phototoxic effects from two photosensitizing drugs.
What to do
Counsel the patient to avoid sun and tanning devices and to use protective clothing and broad-spectrum sunscreen. Stop moxifloxacin if a phototoxic reaction occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Moxifloxacin with Tretinoin?
MediHelp rates the interaction as moderate. Moxifloxacin and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both moxifloxacin and systemic tretinoin can cause photosensitivity, so combined use may increase the risk of exaggerated sunburn-like reactions. The effect is relevant mainly with oral tretinoin and with sun exposure.
How serious is the interaction between Moxifloxacin and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid sun and tanning devices and to use protective clothing and broad-spectrum sunscreen. Stop moxifloxacin if a phototoxic reaction occurs.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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