Drug interactions
Moxonidine + Oxycodone
Severity: Moderate
Moxonidine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine, a centrally acting antihypertensive, can cause drowsiness and lower blood pressure, which may add to opioid sedation and hypotension. The effect is usually modest.
What this interaction means in plain words
Moxonidine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor sedation and blood pressure when starting or increasing either drug, and counsel about dizziness on standing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Moxonidine with Oxycodone?
MediHelp rates the interaction as moderate. Moxonidine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine, a centrally acting antihypertensive, can cause drowsiness and lower blood pressure, which may add to opioid sedation and hypotension. The effect is usually modest.
How serious is the interaction between Moxonidine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure when starting or increasing either drug, and counsel about dizziness on standing.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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