Drug interactions
Moxonidine + Trazodone
Severity: Moderate
Moxonidine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause sedation and low blood pressure, and trazodone adds sedation and alpha-1 blockade. Together they may increase drowsiness, dizziness and orthostatic hypotension.
What this interaction means in plain words
Moxonidine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative and hypotensive effects from central alpha/imidazoline agonism and trazodone's alpha-1 antagonism.
What to do
Monitor blood pressure including standing readings, and start with low doses. Counsel patients to rise slowly and avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Moxonidine with Trazodone?
MediHelp rates the interaction as moderate. Moxonidine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause sedation and low blood pressure, and trazodone adds sedation and alpha-1 blockade. Together they may increase drowsiness, dizziness and orthostatic hypotension.
How serious is the interaction between Moxonidine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings, and start with low doses. Counsel patients to rise slowly and avoid driving if drowsy.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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