Drug interactions
Mycophenolate + Ocrelizumab
Severity: Moderate
Mycophenolate and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress lymphocyte function, so combined use raises the likelihood of bacterial, viral and opportunistic infections. Ocrelizumab labeling advises considering additive immune effects when other immunosuppressants are given.
What this interaction means in plain words
Mycophenolate and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression: B-cell depletion by ocrelizumab plus inhibition of lymphocyte purine synthesis by mycophenolate.
What to do
Monitor for signs of infection and check blood counts and immunoglobulins periodically. Use the lowest effective mycophenolate dose and screen for hepatitis B before starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Mycophenolate with Ocrelizumab?
MediHelp rates the interaction as moderate. Mycophenolate and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress lymphocyte function, so combined use raises the likelihood of bacterial, viral and opportunistic infections. Ocrelizumab labeling advises considering additive immune effects when other immunosuppressants are given.
How serious is the interaction between Mycophenolate and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts and immunoglobulins periodically. Use the lowest effective mycophenolate dose and screen for hepatitis B before starting.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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