Drug interactions
Mycophenolate + Upadacitinib
Severity: Major
Mycophenolate and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress lymphocyte function through different pathways. Together they may substantially increase the risk of serious, opportunistic and viral infections and possibly malignancy. Upadacitinib labeling advises against use with potent immunosuppressants.
What this interaction means in plain words
Mycophenolate and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from JAK inhibition and inhibition of lymphocyte purine synthesis.
What to do
Avoid the combination; choose an alternative regimen. If unavoidable, monitor closely for infection and check blood counts regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Mycophenolate with Upadacitinib?
MediHelp rates the interaction as major. Mycophenolate and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents suppress lymphocyte function through different pathways. Together they may substantially increase the risk of serious, opportunistic and viral infections and possibly malignancy. Upadacitinib labeling advises against use with potent immunosuppressants.
How serious is the interaction between Mycophenolate and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative regimen. If unavoidable, monitor closely for infection and check blood counts regularly.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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