Drug interactions
Mycophenolate mofetil + Pantoprazole
Severity: Moderate
Mycophenolate mofetil and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole raises gastric pH, which can impair dissolution and conversion of mycophenolate mofetil to mycophenolic acid. Mycophenolic acid exposure may fall, potentially reducing immunosuppressive efficacy, as seen in transplant recipients.
What this interaction means in plain words
Mycophenolate mofetil and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces absorption of oral mycophenolate mofetil, which depends on acidic dissolution.
What to do
Consider whether the PPI is necessary, or use enteric-coated mycophenolate sodium, which is less affected. Monitor for signs of rejection or reduced efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Mycophenolate mofetil with Pantoprazole?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pantoprazole raises gastric pH, which can impair dissolution and conversion of mycophenolate mofetil to mycophenolic acid. Mycophenolic acid exposure may fall, potentially reducing immunosuppressive efficacy, as seen in transplant recipients.
How serious is the interaction between Mycophenolate mofetil and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider whether the PPI is necessary, or use enteric-coated mycophenolate sodium, which is less affected. Monitor for signs of rejection or reduced efficacy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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