Drug interactions
Mycophenolate mofetil + Siponimod
Severity: Moderate
Mycophenolate mofetil and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod reduces circulating lymphocytes and mycophenolate suppresses lymphocyte function, so the combination may increase susceptibility to infections. The effect on lymphocyte counts persists for some time after siponimod is stopped.
What this interaction means in plain words
Mycophenolate mofetil and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor-mediated lymphocyte sequestration and inhibition of lymphocyte proliferation.
What to do
Monitor lymphocyte counts and signs of infection during and after combined therapy. Avoid the combination where possible and treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Siponimod?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod reduces circulating lymphocytes and mycophenolate suppresses lymphocyte function, so the combination may increase susceptibility to infections. The effect on lymphocyte counts persists for some time after siponimod is stopped.
How serious is the interaction between Mycophenolate mofetil and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lymphocyte counts and signs of infection during and after combined therapy. Avoid the combination where possible and treat infections promptly.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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