Drug interactions
Mycophenolate mofetil + Ublituximab
Severity: Moderate
Mycophenolate mofetil and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and mycophenolate suppresses lymphocyte proliferation, so combined use can deepen immunosuppression. This raises the risk of serious or opportunistic infections.
What this interaction means in plain words
Mycophenolate mofetil and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression through anti-CD20 B-cell depletion plus inhibition of lymphocyte proliferation by mycophenolic acid.
What to do
Monitor for signs of infection and screen for hepatitis B before ublituximab. Consider the prolonged duration of B-cell depletion when planning any immunosuppressive therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Mycophenolate mofetil with Ublituximab?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and mycophenolate suppresses lymphocyte proliferation, so combined use can deepen immunosuppression. This raises the risk of serious or opportunistic infections.
How serious is the interaction between Mycophenolate mofetil and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and screen for hepatitis B before ublituximab. Consider the prolonged duration of B-cell depletion when planning any immunosuppressive therapy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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