Drug interactions
Mycophenolate mofetil + Valganciclovir
Severity: Moderate
Mycophenolate mofetil and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolic acid glucuronide and ganciclovir are both renally eliminated, and in renal impairment competition for tubular secretion may raise concentrations of both. Both drugs also cause neutropenia, so their toxicity is additive.
What this interaction means in plain words
Mycophenolate mofetil and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion plus additive myelosuppression.
What to do
Monitor complete blood counts closely, especially in patients with reduced renal function. Adjust valganciclovir dose to renal function and reduce or interrupt either drug if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Valganciclovir
Frequently asked questions
Can I take Mycophenolate mofetil with Valganciclovir?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolic acid glucuronide and ganciclovir are both renally eliminated, and in renal impairment competition for tubular secretion may raise concentrations of both. Both drugs also cause neutropenia, so their toxicity is additive.
How serious is the interaction between Mycophenolate mofetil and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely, especially in patients with reduced renal function. Adjust valganciclovir dose to renal function and reduce or interrupt either drug if neutropenia develops.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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