Drug interactions
Nabilone + Nortriptyline
Severity: Moderate
Nabilone and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and each can produce tachycardia and orthostatic hypotension. Combined use may increase sedation, anticholinergic burden and cardiovascular effects.
What this interaction means in plain words
Nabilone and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression with overlapping tachycardic and hypotensive effects.
What to do
Monitor sedation, heart rate and orthostatic blood pressure, particularly in older patients or those with heart disease. Lower the nortriptyline dose if excessive sedation or tachycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nabilone with Nortriptyline?
MediHelp rates the interaction as moderate. Nabilone and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, and each can produce tachycardia and orthostatic hypotension. Combined use may increase sedation, anticholinergic burden and cardiovascular effects.
How serious is the interaction between Nabilone and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and orthostatic blood pressure, particularly in older patients or those with heart disease. Lower the nortriptyline dose if excessive sedation or tachycardia occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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