Drug interactions
Nabilone + Oxazepam
Severity: Moderate
Nabilone and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxazepam is a benzodiazepine and combining it with nabilone can cause additive sedation, memory impairment and psychomotor slowing. The risk of falls and accidents is increased, particularly in older adults.
What this interaction means in plain words
Nabilone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via cannabinoid and GABA-A receptor-mediated effects.
What to do
Use the lowest effective doses and counsel against driving or operating machinery. Reduce the dose of either drug if sedation or confusion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Nabilone with Oxazepam?
MediHelp rates the interaction as moderate. Nabilone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxazepam is a benzodiazepine and combining it with nabilone can cause additive sedation, memory impairment and psychomotor slowing. The risk of falls and accidents is increased, particularly in older adults.
How serious is the interaction between Nabilone and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel against driving or operating machinery. Reduce the dose of either drug if sedation or confusion occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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