Drug interactions
Nabilone + Promethazine
Severity: Moderate
Nabilone and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone causes drowsiness, dizziness and impaired cognition, and promethazine adds to these effects. The combination can impair alertness and increase fall risk.
What this interaction means in plain words
Nabilone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Promethazine belongs to Respiratory.
Why it happens
Additive central nervous system depression.
What to do
Use lower starting doses and advise against driving or operating machinery. Monitor for excessive sedation, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Promethazine?
MediHelp rates the interaction as moderate. Nabilone and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone causes drowsiness, dizziness and impaired cognition, and promethazine adds to these effects. The combination can impair alertness and increase fall risk.
How serious is the interaction between Nabilone and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower starting doses and advise against driving or operating machinery. Monitor for excessive sedation, especially in older adults.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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