Drug interactions
Nabumetone + Naproxen
Severity: Major
Nabumetone and Naproxen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together adds toxicity without improved pain relief, increasing the risk of gastrointestinal bleeding, ulcers and kidney injury. Hyperkalemia and fluid retention can also occur.
What this interaction means in plain words
Nabumetone and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabumetone belongs to Musculoskeletal; Naproxen belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition duplicates gastric, platelet and renal effects.
What to do
Avoid combining; use one NSAID at the lowest effective dose and add gastroprotection if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Naproxen?
MediHelp rates the interaction as major. Nabumetone and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two NSAIDs together adds toxicity without improved pain relief, increasing the risk of gastrointestinal bleeding, ulcers and kidney injury. Hyperkalemia and fluid retention can also occur.
How serious is the interaction between Nabumetone and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use one NSAID at the lowest effective dose and add gastroprotection if needed.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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