Drug interactions
Nabumetone + Paroxetine
Severity: Moderate
Nabumetone and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine and NSAIDs each impair hemostasis, and together they substantially raise the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Nabumetone and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID platelet inhibition and gastric mucosal damage.
What to do
Consider a proton pump inhibitor for gastroprotection and monitor for signs of GI bleeding. Use the lowest effective NSAID dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Nabumetone with Paroxetine?
MediHelp rates the interaction as moderate. Nabumetone and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine and NSAIDs each impair hemostasis, and together they substantially raise the risk of upper gastrointestinal bleeding.
How serious is the interaction between Nabumetone and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection and monitor for signs of GI bleeding. Use the lowest effective NSAID dose or an alternative analgesic.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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