Drug interactions
Nabumetone + Sacubitril-valsartan
Severity: Moderate
Nabumetone and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of sacubitril-valsartan and impair renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia risk may also rise.
What this interaction means in plain words
Nabumetone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins reduces renal perfusion and sodium excretion, adding to the effects of angiotensin receptor blockade on glomerular filtration and potassium handling.
What to do
Avoid regular NSAID use where possible. If needed, use the lowest dose for the shortest time and monitor renal function, serum potassium and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Nabumetone with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Nabumetone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of sacubitril-valsartan and impair renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia risk may also rise.
How serious is the interaction between Nabumetone and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible. If needed, use the lowest dose for the shortest time and monitor renal function, serum potassium and blood pressure.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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