Drug interactions
Nabumetone + Spironolactone
Severity: Major
Nabumetone and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the potassium-excreting and natriuretic effect of spironolactone and impair renal function. This raises the risk of hyperkalemia and acute kidney injury, particularly in older patients, those with kidney disease or heart failure.
What this interaction means in plain words
Nabumetone and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabumetone belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renin and aldosterone and renal perfusion, which adds to aldosterone antagonism and decreases potassium excretion.
What to do
Avoid the combination where possible, especially in patients with renal impairment. If it is necessary, check serum potassium and creatinine within the first week and periodically afterwards.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Nabumetone with Spironolactone?
MediHelp rates the interaction as major. Nabumetone and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the potassium-excreting and natriuretic effect of spironolactone and impair renal function. This raises the risk of hyperkalemia and acute kidney injury, particularly in older patients, those with kidney disease or heart failure.
How serious is the interaction between Nabumetone and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in patients with renal impairment. If it is necessary, check serum potassium and creatinine within the first week and periodically afterwards.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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