Drug interactions
Nabumetone + Streptomycin
Severity: Moderate
Nabumetone and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may decrease renal clearance of aminoglycosides, as seen mainly in premature infants. Both agents can harm the kidney, so renal function matters in any patient receiving both.
What this interaction means in plain words
Nabumetone and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction of renal prostaglandins lowers glomerular filtration and aminoglycoside clearance, with additive nephrotoxicity.
What to do
Monitor renal function and streptomycin levels, and adjust the dose for renal function. Avoid dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Nabumetone with Streptomycin?
MediHelp rates the interaction as moderate. Nabumetone and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may decrease renal clearance of aminoglycosides, as seen mainly in premature infants. Both agents can harm the kidney, so renal function matters in any patient receiving both.
How serious is the interaction between Nabumetone and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels, and adjust the dose for renal function. Avoid dehydration.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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