Drug interactions
Nabumetone + Timolol
Severity: Moderate
Nabumetone and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use can reduce the antihypertensive effect of oral timolol, particularly with sustained use.
What this interaction means in plain words
Nabumetone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and fluid retention that opposes beta-blocker action.
What to do
Monitor blood pressure when the NSAID is started or stopped and adjust antihypertensive therapy as needed. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Nabumetone with Timolol?
MediHelp rates the interaction as moderate. Nabumetone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use can reduce the antihypertensive effect of oral timolol, particularly with sustained use.
How serious is the interaction between Nabumetone and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started or stopped and adjust antihypertensive therapy as needed. Consider paracetamol as an alternative.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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