Drug interactions
Nabumetone + Tobramycin
Severity: Moderate
Nabumetone and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce aminoglycoside clearance, which has been documented chiefly in preterm infants. Both classes carry nephrotoxic potential, so concurrent use may increase the risk of kidney injury and aminoglycoside toxicity.
What this interaction means in plain words
Nabumetone and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular filtration and aminoglycoside clearance, with additive nephrotoxicity.
What to do
Monitor serum creatinine and tobramycin trough levels, and adjust the dose accordingly. Avoid the NSAID in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Nabumetone with Tobramycin?
MediHelp rates the interaction as moderate. Nabumetone and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce aminoglycoside clearance, which has been documented chiefly in preterm infants. Both classes carry nephrotoxic potential, so concurrent use may increase the risk of kidney injury and aminoglycoside toxicity.
How serious is the interaction between Nabumetone and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust the dose accordingly. Avoid the NSAID in patients with renal impairment or volume depletion.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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