Drug interactions
Nabumetone + Tolvaptan
Severity: Minor
Nabumetone and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is a vasopressin antagonist that causes aquaresis, and NSAIDs can impair renal function and perfusion. Together they could increase the risk of volume depletion and acute kidney injury. The labeled potassium concern is minor and there is no well-documented direct interaction.
What this interaction means in plain words
Nabumetone and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nabumetone belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
NSAID-induced reduction of renal prostaglandins may add to the fluid loss caused by tolvaptan; there is no established pharmacokinetic interaction.
What to do
Monitor renal function, serum sodium and hydration status when the combination is used. Stop the NSAID if creatinine rises or volume depletion develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Nabumetone with Tolvaptan?
MediHelp rates the interaction as minor. Nabumetone and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan is a vasopressin antagonist that causes aquaresis, and NSAIDs can impair renal function and perfusion. Together they could increase the risk of volume depletion and acute kidney injury. The labeled potassium concern is minor and there is no well-documented direct interaction.
How serious is the interaction between Nabumetone and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, serum sodium and hydration status when the combination is used. Stop the NSAID if creatinine rises or volume depletion develops.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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