Drug interactions
Nabumetone + Triamterene
Severity: Major
Nabumetone and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs combined with triamterene raise the risk of hyperkalemia and acute kidney injury. The combination has been associated with reduced renal function, and triamterene is itself a recognised nephrotoxic risk when used with NSAIDs.
What this interaction means in plain words
Nabumetone and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabumetone belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAIDs reduce renal prostaglandin-dependent perfusion and aldosterone release, while triamterene blocks potassium secretion, producing additive potassium retention and renal hemodynamic injury.
What to do
Avoid the combination, particularly in patients with renal impairment or older age. If both are used, monitor serum potassium and creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Nabumetone with Triamterene?
MediHelp rates the interaction as major. Nabumetone and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs combined with triamterene raise the risk of hyperkalemia and acute kidney injury. The combination has been associated with reduced renal function, and triamterene is itself a recognised nephrotoxic risk when used with NSAIDs.
How serious is the interaction between Nabumetone and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, particularly in patients with renal impairment or older age. If both are used, monitor serum potassium and creatinine closely.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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