Drug interactions
Nadolol + Oxaprozin
Severity: Moderate
Nadolol and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may weaken the antihypertensive effect of nadolol, especially with continued use. Blood pressure control can deteriorate.
What this interaction means in plain words
Nadolol and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and water retention antagonize beta-blocker effect.
What to do
Monitor blood pressure when the NSAID is started, changed or stopped, and adjust antihypertensive therapy as needed. Prefer paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Oxaprozin?
MediHelp rates the interaction as moderate. Nadolol and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may weaken the antihypertensive effect of nadolol, especially with continued use. Blood pressure control can deteriorate.
How serious is the interaction between Nadolol and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, changed or stopped, and adjust antihypertensive therapy as needed. Prefer paracetamol where suitable.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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