Drug interactions
Nadolol + Phentolamine
Severity: Moderate
Nadolol and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is an alpha-blocker vasodilator and nadolol is a nonselective beta-blocker, so combined use lowers blood pressure more than either alone. Hypotension and reflex effects may occur, and beta-blockade may blunt the reflex tachycardia that normally accompanies phentolamine.
What this interaction means in plain words
Nadolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects from alpha-adrenergic and beta-adrenergic blockade.
What to do
Monitor blood pressure and heart rate closely, particularly during phentolamine infusion. Adjust doses as needed to avoid symptomatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phentolamine
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Phentolamine?
MediHelp rates the interaction as moderate. Nadolol and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is an alpha-blocker vasodilator and nadolol is a nonselective beta-blocker, so combined use lowers blood pressure more than either alone. Hypotension and reflex effects may occur, and beta-blockade may blunt the reflex tachycardia that normally accompanies phentolamine.
How serious is the interaction between Nadolol and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, particularly during phentolamine infusion. Adjust doses as needed to avoid symptomatic hypotension.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
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