Drug interactions
Nadolol + Pilocarpine
Severity: Moderate
Nadolol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a cholinergic agonist that can slow heart rate and conduction, and nadolol also lowers heart rate and AV conduction. Together they may produce additive bradycardia or conduction disturbances, and nadolol may blunt compensatory responses to pilocarpine-induced bronchoconstriction.
What this interaction means in plain words
Nadolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on heart rate and AV conduction from muscarinic stimulation and beta-adrenergic blockade.
What to do
Monitor heart rate, blood pressure and respiratory symptoms when starting or adjusting pilocarpine in a patient on nadolol. Use particular care in patients with conduction disease or asthma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Nadolol with Pilocarpine?
MediHelp rates the interaction as moderate. Nadolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a cholinergic agonist that can slow heart rate and conduction, and nadolol also lowers heart rate and AV conduction. Together they may produce additive bradycardia or conduction disturbances, and nadolol may blunt compensatory responses to pilocarpine-induced bronchoconstriction.
How serious is the interaction between Nadolol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and respiratory symptoms when starting or adjusting pilocarpine in a patient on nadolol. Use particular care in patients with conduction disease or asthma.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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