Drug interactions
Nadolol + Secobarbital
Severity: Minor
Nadolol and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower exposure to some beta-blockers that are hepatically metabolized. Nadolol is eliminated mostly unchanged by the kidneys, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Nadolol and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nadolol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate hepatic enzyme induction, which has little impact on renally cleared nadolol.
What to do
No dose change is normally needed; monitor heart rate and blood pressure when starting or stopping the barbiturate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Secobarbital?
MediHelp rates the interaction as minor. Nadolol and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates can lower exposure to some beta-blockers that are hepatically metabolized. Nadolol is eliminated mostly unchanged by the kidneys, so a clinically meaningful effect is unlikely.
How serious is the interaction between Nadolol and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor heart rate and blood pressure when starting or stopping the barbiturate.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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