Drug interactions
Nadolol + Tolazamide
Severity: Moderate
Nadolol and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers like nadolol can blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay glucose recovery. They can also modestly impair glycemic control, so hypoglycemia on a sulfonylurea may go unrecognized.
What this interaction means in plain words
Nadolol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Beta-adrenergic blockade masks hypoglycemia symptoms and inhibits glycogenolysis-mediated recovery.
What to do
Monitor blood glucose more often and counsel patients that sweating may be the main remaining warning sign. Consider a cardioselective beta-blocker if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Tolazamide?
MediHelp rates the interaction as moderate. Nadolol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers like nadolol can blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay glucose recovery. They can also modestly impair glycemic control, so hypoglycemia on a sulfonylurea may go unrecognized.
How serious is the interaction between Nadolol and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and counsel patients that sweating may be the main remaining warning sign. Consider a cardioselective beta-blocker if clinically appropriate.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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