Drug interactions
Nadolol + Tolbutamide
Severity: Moderate
Nadolol and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers like nadolol can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay glucose recovery. They may also modestly impair glycemic control.
What this interaction means in plain words
Nadolol and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Beta-adrenergic blockade masks hypoglycemia symptoms and inhibits glycogenolysis and counter-regulation.
What to do
Monitor blood glucose more frequently and tell the patient that sweating may be the main warning sign. Consider a cardioselective beta-blocker if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Tolbutamide?
MediHelp rates the interaction as moderate. Nadolol and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers like nadolol can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations, and may delay glucose recovery. They may also modestly impair glycemic control.
How serious is the interaction between Nadolol and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and tell the patient that sweating may be the main warning sign. Consider a cardioselective beta-blocker if appropriate.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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