Drug interactions
Nadolol + Tolfenamic acid
Severity: Moderate
Nadolol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid may weaken the antihypertensive effect of nadolol during regular use. Renal function and fluid balance may also be affected.
What this interaction means in plain words
Nadolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention, opposing beta-blocker effects.
What to do
Monitor blood pressure with repeated NSAID use. Use the lowest effective dose for the shortest time or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Nadolol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Nadolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid may weaken the antihypertensive effect of nadolol during regular use. Renal function and fluid balance may also be affected.
How serious is the interaction between Nadolol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure with repeated NSAID use. Use the lowest effective dose for the shortest time or an alternative analgesic.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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