Drug interactions
Nadolol + Trilaciclib
Severity: Moderate
Nadolol and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE-2K, which could reduce renal clearance of nadolol and raise its levels. Nadolol is mainly renally eliminated, so exposure may increase and enhance beta-blockade.
What this interaction means in plain words
Nadolol and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of renal transporters may reduce nadolol tubular secretion and increase its exposure.
What to do
Monitor heart rate and blood pressure around trilaciclib infusion and reduce nadolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nadolol and Trilaciclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Trilaciclib
Frequently asked questions
Can I take Nadolol with Trilaciclib?
MediHelp rates the interaction as moderate. Nadolol and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits renal transporters OCT2, MATE1 and MATE-2K, which could reduce renal clearance of nadolol and raise its levels. Nadolol is mainly renally eliminated, so exposure may increase and enhance beta-blockade.
How serious is the interaction between Nadolol and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure around trilaciclib infusion and reduce nadolol dose if bradycardia or hypotension develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
