Drug interactions
Nadolol + Umeclidinium-vilanterol
Severity: Major
Nadolol and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta blocker that antagonizes beta-2 receptors in the airways and can blunt vilanterol's bronchodilation. It may precipitate bronchospasm in patients with COPD or asthma.
What this interaction means in plain words
Nadolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nadolol belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Avoid non-selective beta blockers in patients with obstructive airway disease. If a beta blocker is required, switch to a cardioselective agent and monitor respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Nadolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta blocker that antagonizes beta-2 receptors in the airways and can blunt vilanterol's bronchodilation. It may precipitate bronchospasm in patients with COPD or asthma.
How serious is the interaction between Nadolol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta blockers in patients with obstructive airway disease. If a beta blocker is required, switch to a cardioselective agent and monitor respiratory status.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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