Drug interactions
Nafcillin + Nevirapine
Severity: Moderate
Nafcillin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may lower nevirapine concentrations and risk reduced antiviral effect during treatment. The effect is based on enzyme induction and case reports with other drugs.
What this interaction means in plain words
Nafcillin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4 and CYP2B6, increasing nevirapine clearance.
What to do
Monitor HIV RNA during therapy and consider an alternative antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nafcillin with Nevirapine?
MediHelp rates the interaction as moderate. Nafcillin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin may lower nevirapine concentrations and risk reduced antiviral effect during treatment. The effect is based on enzyme induction and case reports with other drugs.
How serious is the interaction between Nafcillin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV RNA during therapy and consider an alternative antibiotic when possible.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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