Drug interactions
Nafcillin + Oxycodone
Severity: Moderate
Nafcillin and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may lower oxycodone concentrations, with possible loss of analgesic effect or withdrawal in opioid-dependent patients. The effect is described mainly for other CYP3A4 substrates and is likely variable.
What this interaction means in plain words
Nafcillin and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases oxycodone clearance.
What to do
Monitor pain control and withdrawal during nafcillin therapy and adjust the oxycodone dose; watch for toxicity after nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Nafcillin with Oxycodone?
MediHelp rates the interaction as moderate. Nafcillin and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and may lower oxycodone concentrations, with possible loss of analgesic effect or withdrawal in opioid-dependent patients. The effect is described mainly for other CYP3A4 substrates and is likely variable.
How serious is the interaction between Nafcillin and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal during nafcillin therapy and adjust the oxycodone dose; watch for toxicity after nafcillin is stopped.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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